Effect of inactivation and disinhibition of the oculomotor vermis on saccade...

 

 

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Effect of inactivation and disinhibition of the oculomotor vermis on saccade adaptation

via ScienceDirect Publication: Brain Research on 5/19/11

Publication year: 2011
Source: Brain Research, In Press, Accepted Manuscript, Available online 19 May 2011
Yoshiko, Kojima , Robijanto, Soetedjo , Albert F., Fuchs
The ability to adapt a variety of motor acts to compensate for persistent natural or artificially induced errors in movement accuracy requires the cerebellum. For adaptation of the rapid shifts in the direction of gaze called saccades, the oculomotor vermis (OMV) of the cerebellum must be intact. We disrupted the neural circuitry of the OMV by manipulating gamma aminobutyric acid (GABA), the transmitter used by many neurons in the vermis. We injected either muscimol, an agonist of GABA, to inactivate the OMV or bicuculline, an antagonist, to block GABA inhibition. Our previous study showed that muscimol injections cause ipsiversive saccades...
 Research highlights: ► GABA agonist and antagonist were injected into the oculomotor vermis (OMV). ► Saccade amplitude increase and decrease adaptation (UP/DOWN) were tested. ► Agonist abolished UP, but had no effect on DOWN. ► Antagonist facilitated UP and slowed DOWN. ► Results suggest OMV is necessary for UP, and DOWN may involve inhibitory circuits.

 

 

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